反応式
[CH3:1][C:2]1([CH3:16])[NH:13][C:12]([CH3:15])([CH3:14])[CH2:11][C:4]2([NH:8][C:7](=[O:9])[NH:6][C:5]2=[O:10])[CH2:3]1.[O:17]1[CH2:41][CH:18]1[CH2:19][O:20][CH:21]1[CH2:26][CH2:25][CH:24]([C:27]([CH:30]2[CH2:35][CH2:34][CH:33]([O:36][CH2:37][CH:38]3[O:40][CH2:39]3)[CH2:32][CH2:31]2)([CH3:29])[CH3:28])[CH2:23][CH2:22]1.[OH-:42].[K+]>CO>[OH:17][CH:18]([CH2:41][N:6]1[C:5](=[O:42])[C:4]2([CH2:3][C:2]([CH3:1])([CH3:16])[NH:13][C:12]([CH3:15])([CH3:14])[CH2:11]2)[NH:8][C:7]1=[O:9])[CH2:19][O:20][CH:21]1[CH2:22][CH2:23][CH:24]([C:27]([CH:30]2[CH2:31][CH2:32][CH:33]([O:36][CH2:37][CH:38]([OH:40])[CH2:39][N:6]3[C:5](=[O:10])[C:4]4([CH2:3][C:2]([CH3:16])([CH3:1])[NH:13][C:12]([CH3:15])([CH3:14])[CH2:11]4)[NH:8][C:7]3=[O:9])[CH2:34][CH2:35]2)([CH3:29])[CH3:28])[CH2:25][CH2:26]1参加物
5
反応物 3
生成物 1
試薬・触媒・溶媒 1
実験手順
40.0 g of 7,7,9,9-tetramethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione, 17.5 g of 2,2-bis[4-(2,3-epoxypropoxy)cyclohexyl]propane and 2.0 g of potassium hydroxide were reacted in 300 ml of methanol, following substantially the same procedure as was described in Example 1. The desired Compound No. 118 was obtained in the form of a white powder, having an Rf value of 0.56 on thin-layer chromatography on silica gel using a 8:1:1:1 by volume mixture of ethyl acetate, benzene, ethanol and triethylamine as developing solvent.
出典と根拠
- ORDレコード
- ord-365dedf39dcc46aca604c0a98528e130
- 出典データセット
- uspto-grants-1979_07
- 特許番号
- US04162246
関連ノート
読み込み中…