Benzene → HCID 13239466、化合物

HRID 972246ノート

反応式

HRID 972246 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]=[C:13]([Cl:15])[CH:14]=1)[O:5][CH:6]([CH2:10][CH3:11])[C:7](O)=[O:8].C1C=CC=CC=1.C(Cl)([Cl:24])=O.Cl>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]=[C:13]([Cl:15])[CH:14]=1)[O:5][CH:6]([CH2:10][CH3:11])[C:7]([Cl:24])=[O:8]

参加物

6

反応物 4

HCID 241BenzeneHCID 313Hydrochloric Acid2 回HCID 6371Phosgene2 回HCID 130607432-(3,5-Dichlorophenoxy)butanoic acid

生成物 1

HCID 13239466HCID 13239466、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
35 °C

実験手順

71.8 g. (0.288 moles) of α-(3,5-dichlorophenoxy) butyric acid and 75 ml. of benzene are placed in a 500 ml. flask to which a dropping funnel with dry-ice condenser is attached. The slurry is stirred and the 0.2 ml. dimethyl formamide is added. The mixture is heated to 35° C. and 10 g. of phosgene is condensed into the mixture to initiate reaction. The start of the reaction is evidenced by HCl evolution and foaming. 26.0 g. more phosgene is added in 5 gm. increments. At the conclusion of the reaction (HCl evolution ceasing), the reaction mixture is evaporated leaving a residual liquid α-(3,5-dichlorophenoxy) butyryl chloride 77.6g., ND20 = 1.5345

後処理

  1. customflask to which a dropping funnel with dry-ice condenser is attached
  2. customcondensed into the mixture
  3. customreaction
  4. customthe reaction mixture is evaporated

出典と根拠

ORDレコード
ord-5504110c08274aaf8befd70eb30ff0bf
出典データセット
uspto-grants-1977_10
特許番号
US04052432

反応ノート

読み込み中…