Tetrafluoroboric acid → HCID 21406771、化合物

反応式

[C:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=2[F:17])=[C:6](N)[CH:5]=1)(=[O:3])[CH3:2].[H+].[B-](F)(F)(F)[F:21]>>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=2[F:17])=[C:6]([F:21])[CH:5]=1)(=[O:3])[CH3:2]

参加物

反応物 2

HCID 28118Tetrafluoroboric acid

HCID 21320565HCID 21320565、化合物

生成物 1

HCID 21406771HCID 21406771、化合物

実験手順

4-Acetyl-2-amino-2',4'-difluorobiphenyl prepared as described in Example 1 was subjected to the Schiemann reaction using fluoboric acid to give 4-acetyl-2,2',4'-trifluorobiphenyl, m.p. 92°-94° C. By a similar method, starting from the appropriate products of Example 1, there were obtained 4-acetyl-4'-chloro-2,2'-difluorobiphenyl, m.p. 69°-70° C. and 4-acetyl-4'-bromo-2,2'-difluorobiphenyl, m.p. 75°-76° C.

後処理

customwas subjected to the Schiemann reaction

出典と根拠

ORDレコード: ord-d3b85b3e549a4c5b80f704feec729f74
出典データセット: uspto-grants-1977_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04052514

反応ノート

読み込み中…

参加物