化工社化工社 化学情報印刷レポート · 研究参考用
Water → 2-(1,1-dimethyl-2-hydroxyethyl)-5-nitro-2,3-dihydro-1H-isoindol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2-Amino-2-methyl-1-propanol | HCID 11807 | — |
| 反応物 | 4-Nitrophthalic acid anhydride | HCID 230976 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-(1,1-dimethyl-2-hydroxyethyl)-5-nitro-2,3-dihydro-1H-isoindol | HCID 21988156 | — |
反応手順
20 g of 4-Nitro-phthalic anhydride and 8.94 g of 2-amino-2-methylpropanol were heated to 170° C. for 30 min. After cooling, water and CH2Cl2 were added, and the organic phase separated, concentrated and purified by chromatography on silica (eluent CH2Cl2/MeOH 97/3).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091345B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-a28dfc986e8549b3bda0a7e2c9a0bc50 |
| 出典メモ | uspto-grants-2006_08 |