Sulfuric Acid → 3-Methoxyisothiazole-4-carboxamide
反応式
[C:1]([C:3]1[C:4]([O:8][CH3:9])=[N:5][S:6][CH:7]=1)#[N:2].S(=O)(=O)(O)[OH:11]>>[C:1]([C:3]1[C:4]([O:8][CH3:9])=[N:5][S:6][CH:7]=1)(=[O:11])[NH2:2]参加物
3
実験手順
A solution of 2.8 g. (0.02 mole) of 4-cyano-3-methoxyisothiazole prepared as in Example 18 in 30 ml. of 75% sulfuric acid was heated at 70° C. for 0.5 hour. The solution was then cooled and poured into ice to give after filtration and drying 0.95 g. of 4-carbamoyl-3-methoxyisothiazole, m.p. 165°-168° C. By continuous ether extraction of the aqueous filtrate an addition 1.13 g. of 4-carbamoyl-3-methoxyisothiazole was obtained to give a total yield of 2.08 g. (66%).
後処理
- temperatureThe solution was then cooled
- additionpoured into ice
- customto give
- filtrationafter filtration
- customdrying 0.95 g
- extractionBy continuous ether extraction of the aqueous filtrate
- additionan addition 1.13 g
出典と根拠
- ORDレコード
- ord-29119baf591440129ad6e823bb92f536
- 出典データセット
- uspto-grants-1977_10
- 特許番号
- US04053479
反応ノート
読み込み中…