Ammonia → HCID 21404982、化合物

HRID 972658ノート

反応式

HRID 972658 の反応式
C[O:2][C:3]1[CH:4]=[C:5]([NH:11][C:12]([C:14]23[CH2:23][CH:18]4[CH2:19][CH:20]([CH2:22][CH:16]([CH2:17]4)[CH2:15]2)[CH2:21]3)=[O:13])[CH:6]=[CH:7][C:8]=1[O:9]C.B(I)(I)I.C(Cl)Cl.N>C(O)C>[OH:2][C:3]1[CH:4]=[C:5]([NH:11][C:12]([C:14]23[CH2:23][CH:18]4[CH2:17][CH:16]([CH2:22][CH:20]([CH2:19]4)[CH2:21]2)[CH2:15]3)=[O:13])[CH:6]=[CH:7][C:8]=1[OH:9]

参加物

6

反応物 4

HCID 222AmmoniaHCID 6344DichloromethaneHCID 83546Borane, triiodo-HCID 4333080HCID 4333080、化合物

生成物 1

HCID 21404982HCID 21404982、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Subject 2.0 g. of N-(3,4-dimethoxyphenyl)-1-adamantanecarboxamide and 2.5 g. of boron triiodide to the procedure set forth in Example 6B. Chromatograph the residue obtained thereby on a column containing 35 g. of silica gel using as the eluent a methylene chloride:ethanol: conc. ammonia (90:10:4 v/v). Crystallize the product from chloroform to obtain the product of this Example, m.p. 196°-199° C.

後処理

  1. customChromatograph the residue obtained
  2. additionon a column containing 35 g
  3. customCrystallize the product from chloroform
  4. customto obtain the product of this Example, m.p. 196°-199° C.

出典と根拠

ORDレコード
ord-beb00206d28d4bed8835a4ad593e7c50
出典データセット
uspto-grants-1977_10
特許番号
US04053509

反応ノート

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