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Dimethyl Sulfoxide → 6-[p-(4-Piperidinopiperidino)phenyl]-1,2-dihydro-2-oxonicotinonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl Sulfoxide | HCID 679 | — |
| 反応物 | 1,4'-Bipiperidine | HCID 78607 | — |
| 反応物 | 6-(4-Fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile | HCID 2765203 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 6-[p-(4-Piperidinopiperidino)phenyl]-1,2-dihydro-2-oxonicotinonitrile | HCID 21404522 | — |
反応手順
A mixture of 10.7 g. of 6-(p-fluorophenyl)-1,2-dihydro-2-oxonicotinonitrile [J. Med. Chem. 14, 342 (1971)] and 16.8 g. of 4-piperidinopiperidine in 140 ml. of dimethyl sulfoxide is stirred and heated at 95°-100° for 50 hours. The mixture is cooled and diluted with 450 ml. of 95% ethanol. The resulting precipitate of 6-[p-(4-piperidinopiperidino)phenyl]-1,2-dihydro-2-oxonicotinonitrile is collected by filtration, washed with 95% ethanol and dried; m.p. 288°-293° (dec.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04053470 |
| 出典データセット | uspto-grants-1977_10 |
| ORD ID | ord-0a73f4e52c7e4167862210c979e4bd9a |
| 出典メモ | uspto-grants-1977_10 |