Bromide ion → HCID 57489126、化合物

HRID 972736ノート

反応式

HRID 972736 の反応式
[Br-].[F:2][C:3]1[CH:16]=[CH:15][CH:14]=[CH:13][C:4]=1[CH2:5][N:6]1[CH:10]=[CH:9][CH:8]=[C:7]1[CH:11]=[O:12].[Cl-].[NH4+:18].CCO[CH2:22][CH3:23]>>[F:2][C:3]1[CH:16]=[CH:15][CH:14]=[CH:13][C:4]=1[CH2:5][N:6]1[CH:10]=[CH:9][CH:8]=[C:7]1[CH:11]([OH:12])[CH2:10][CH2:9][CH2:8][N:18]1[CH2:4][CH2:5][N:6]([C:23]2[CH:22]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:7][CH2:11]1

参加物

5

反応物 4

HCID 259Bromide ionHCID 3283Diethyl EtherHCID 25517Ammonium Chloride2 回HCID 10891841-[(2-Fluorophenyl)methyl]-1H-pyrrole-2-carbaldehyde

生成物 1

HCID 57489126HCID 57489126、化合物

反応条件

温度
45 °C

実験手順

The Grignard reagent of 4-phenylpiperaznopropylmagnesium bromide is added to benzane and the mixture is refluxed at 45°C for 1 hour. The mixture is permitted to cool and a solution of 1-(2-fluorobenzyl)pyrrole-2-carboxaldehyde in ether is added and then the mixture is stirred at 45°C for 20 hours. The reaction is permitted to cool, poured into ammonium chloride solution and the ammonium chloride solution is stirred for 30 minutes and extracted with chloroform. The combined chloroform extracts are washed well with water, dried and filtered and the solvent removed leaving 1-[1-(2-fluorobenyl)-2-pyrryl]-4-(4-phenylpiperazino)butanol.

後処理

  1. temperatureto cool
  2. temperatureto cool
  3. extractionextracted with chloroform
  4. washThe combined chloroform extracts are washed well with water
  5. customdried
  6. filtrationfiltered
  7. customthe solvent removed

出典と根拠

ORDレコード
ord-53d15405665a4fc39bf26f8452d6f27f
出典データセット
uspto-grants-1977_10
特許番号
US04053599

反応ノート

読み込み中…