Tert-Butylamine → HCID 20309603、化合物

HRID 972796ノート

反応式

HRID 972796 の反応式
[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([O:19][CH2:20][CH:21]2[O:23][CH2:22]2)=[C:9]([CH:18]=1)[C:10]([CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[O:11])(=[O:3])[CH3:2].[C:24]([NH2:28])([CH3:27])([CH3:26])[CH3:25]>CO>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([O:19][CH2:20][CH:21]([OH:23])[CH2:22][NH:28][C:24]([CH3:27])([CH3:26])[CH3:25])=[C:9]([CH:18]=1)[C:10]([CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[O:11])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 6385Tert-ButylamineHCID 20309567HCID 20309567、化合物

生成物 1

HCID 20309603HCID 20309603、化合物収率 33%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of methyl 3-[5-acetamido-2-(2,3-epoxypropoxy)benzoyl]propionate (0.52 g, 0.0016 mole), t-butylamine (20 ml) and methanol (10 ml) was heated under reflux for 16 hours. Evaporation of the reaction mixture left an oil which was dissolved in ethanol and treated with ether to give crystalline methyl 3-[5-acetamido-2-(3-t-butylamino-2-hydroxypropoxy)benzoyl]propionate (0.21 g, 33%; m.p. 127°-128°).

後処理

  1. temperatureunder reflux for 16 hours
  2. customEvaporation of the reaction mixture
  3. waitleft an oil which
  4. dissolutionwas dissolved in ethanol
  5. additiontreated with ether

出典と根拠

ORDレコード
ord-2454a1286b5940128dce8d8198923ab1
出典データセット
uspto-grants-1977_10
特許番号
US04053601

反応ノート

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