Potassium Hydroxide → 2-Propyl-5-thiazole-acetic acid
反応式
[CH2:1]([C:4]1[S:5][C:6]([CH2:9][C:10]([O:12]CC)=[O:11])=[CH:7][N:8]=1)[CH2:2][CH3:3].[OH-].[K+]>CO>[CH2:1]([C:4]1[S:5][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:7][N:8]=1)[CH2:2][CH3:3]参加物
4
実験手順
A mixture of 2.13 g of ethyl 2-propyl-5-thiazole acetate, 11 ml of methanol and 1.1 ml of potassium hydroxide was stirred for 1 hour under a nitrogen atmosphere at room temperature and the methanol was distilled under reduced pressure. The residue was dissolved in 5 ml of water and 2 ml of concentrated hydrochloric acid and then 2.1 g of sodium acetate were added thereto. The mixture was extracted with methylene chloride and the organic extracts were dried and evaporated to dryness. The residue was crystallized from toluene to obtain 1.24g of 2-propyl-5-thiazole-acetic acid melting at 95° C.
後処理
- distillationthe methanol was distilled under reduced pressure
- dissolutionThe residue was dissolved in 5 ml of water
- addition2 ml of concentrated hydrochloric acid and then 2.1 g of sodium acetate were added
- extractionThe mixture was extracted with methylene chloride
- customthe organic extracts were dried
- customevaporated to dryness
- customThe residue was crystallized from toluene
出典と根拠
- ORDレコード
- ord-2648237ccd9e4539a84c3db7c59c2720
- 出典データセット
- uspto-grants-1977_10
- 特許番号
- US04053618
反応ノート
読み込み中…