Phosgene → 5-Fluorobenzothiazol-2-yl isocyanate
反応式
[C:1](Cl)(Cl)=[O:2].[NH2:5][C:6]1[S:7][C:8]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:9]=2[N:10]=1>C(OCC)(=O)C>[F:15][C:12]1[CH:13]=[CH:14][C:8]2[S:7][C:6]([N:5]=[C:1]=[O:2])=[N:10][C:9]=2[CH:11]=1参加物
4
実験手順
A saturated solution of phosgene in ethyl acetate (200 ml) is charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. 2-Amino-5-fluorobenzothiazole (0.1 mole) is added with stirring. After the addition is completed, the reaction mixture is heated at reflux for a period of about one hour. After this time the mixture is cooled, and the solid product formed is recovered by filtration. The solid is then dried to yield the desired product 5-fluorobenzothiazol -2-yl isocyanate dimer.
後処理
- customequipped with a mechanical stirrer
- temperaturethermometer and reflux condenser
- additionAfter the addition
- temperaturethe reaction mixture is heated
- temperatureat reflux for a period of about one hour
- temperatureAfter this time the mixture is cooled
- customthe solid product formed
- filtrationis recovered by filtration
- customThe solid is then dried
出典と根拠
- ORDレコード
- ord-a5f153098f684c4ebcd299686a839b88
- 出典データセット
- uspto-grants-1977_10
- 特許番号
- US04054574
反応ノート
読み込み中…