Hydrochloric Acid → cis-1-hydroxy-3-(1,1-dimethylheptyl)-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]-pyran-9-one

HRID 972940ノート

反応式

HRID 972940 の反応式
C[O:2][C:3]1[CH2:8][CH:7]=[C:6]([C:9]([OH:12])([CH3:11])[CH3:10])[CH2:5][CH:4]=1.[CH3:13][C:14]([C:22]1[CH:23]=[C:24](O)[CH:25]=[C:26]([CH:28]=1)[OH:27])([CH3:21])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20].B(F)(F)F.CCOCC.Cl>C1C=CC=CC=1>[OH:27][C:26]1[C:25]2[C@H:5]3[CH2:4][C:3](=[O:2])[CH2:8][CH2:7][C@H:6]3[C:9]([CH3:11])([CH3:10])[O:12][C:24]=2[CH:23]=[C:22]([C:14]([CH3:13])([CH3:21])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH:28]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 8000Boron trifluoride etherateHCID 918705-(1,1-Dimethylheptyl)resorcinolHCID 64542264-Methoxy-alpha,alpha-dimethylcyclohexa-1,4-diene-1-methanol

生成物 1

HCID 86735145cis-1-hydroxy-3-(1,1-dimethylheptyl)-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]-pyran-9-one

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

反応条件

温度
24 °C

実験手順

A solution of 504 mg. of 1-methoxy-4-(1-hydroxy-1-methylethyl)-1,4-cyclohexadiene and 708 mg. of 5-(1,1-dimethylheptyl)resorcinol in 25 ml. of benzene was stirred at 24° C. while 5 ml. of boron trifluoride diethyl etherate was added in one portion. The reaction mixture was stirred at 24° C. for five hours. The reaction mixture then was added to 20 ml. of 6N hydrochloric acid solution. After allowing the benzene solvent to evaporated from the aqueous acid solution, the solution was extracted several times with diethyl ether. The ethereal extracts were combined, washed with water and with aqueous sodium bicarbonate solution, and dried. Evaporation of the solvent under reduced pressure provided an oil, which was crystallized from hexane to afford dl-cis-1-hydroxy-3-(1,1-dimethylheptyl)-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one.

後処理

  1. additionThe reaction mixture then was added to 20 ml
  2. customto evaporated from the aqueous acid solution
  3. extractionthe solution was extracted several times with diethyl ether
  4. washwashed with water and with aqueous sodium bicarbonate solution
  5. customdried
  6. customEvaporation of the solvent under reduced pressure
  7. customprovided an oil, which
  8. customwas crystallized from hexane

出典と根拠

ORDレコード
ord-97e3355fba9046708c1a553c7955e29e
出典データセット
uspto-grants-1977_10
特許番号
US04054582

反応ノート

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