Ethylamine → HCID 68122832、化合物

HRID 973121ノート

反応式

HRID 973121 の反応式
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6](Cl)[N:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[N:3]=1.C([N:18]([CH2:21][CH3:22])CC)C.[CH2:23]([NH2:25])[CH3:24]>C(O)C>[CH2:23]([NH:25][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([NH:18][CH2:21][CH3:22])[N:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[N:3]=1)[CH3:24]

参加物

5

反応物 3

HCID 6341EthylamineHCID 8471TriethylamineHCID 214008694,6-Dichloro-5-nitro-2-(trifluoromethyl)pyrimidine

生成物 1

HCID 68122832HCID 68122832、化合物収率 98.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

5.25 g (0.02 mol) of 4,6-dichloro-5-nitro-2-trifluoromethyl-pyrimidine (J. Org. Chem. 26 (1961), pp. 4504-8) are dissolved in 150 ml of abs. ethanol. The solution is treated with 5 ml of triethylamine (0.05 mol) and 4.5 g (0.1 mol) of ethylamine and the mixture is stirred overnight, then evaporated to dryness. The residue is taken up in ether and washed with water. The ethereal phase is dried and concentrated to yield 5.5 g of 4,6-bis-ethylamino-5-nitro-2-trifluoromethyl-pyrimidine; m.p. 60°-65° C.

後処理

  1. dissolution4504-8) are dissolved in 150 ml of abs
  2. customevaporated to dryness
  3. washwashed with water
  4. customThe ethereal phase is dried
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-4d8667de238e48dc9ca1cb45d690dc9e
出典データセット
uspto-grants-1977_10
特許番号
US04055411

反応ノート

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