Acetic Acid → 4-methyl-2,7-diphenyl-1H-pyrazolo[3,4-b]pyridine-3,6-dione

HRID 973387

反応式

HRID 973387 の反応式
[C:1]1([N:7]2[C:11](=[O:12])[CH2:10][C:9]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:20](OCC)(=[O:25])[CH2:21][C:22]([CH3:24])=O.C(O)(=O)C>O>[C:1]1([N:7]2[C:11](=[O:12])[C:10]3[C:22]([CH3:24])=[CH:21][C:20](=[O:25])[N:13]([C:14]4[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=4)[C:9]=3[NH:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 8868Ethyl AcetoacetateHCID 178516394HCID 178516394、化合物

生成物 1

HCID 3603164-methyl-2,7-diphenyl-1H-pyrazolo[3,4-b]pyridine-3,6-dione収率 34.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 25 g of 1-phenyl-3-anilino-2-pyrazolin-5-one, 18 g of ethyl acetoacetate, and 150 ml of acetic acid was heat-refluxed for 6 hours. The reaction mixture was diluted with water, and the formed solid was crystallized from acetonitrile to obtain 10.9 g of 2,7-diphenyl-4-methylpyrazolo[3,4-b]pyridine-3,6-dione having a melting point of 145° to 147° C.

後処理

  1. temperaturewas heat-refluxed for 6 hours
  2. customthe formed solid was crystallized from acetonitrile

出典と根拠

ORDレコード
ord-4d3dc8d772864b85895b69c896b30bf7
出典データセット
uspto-grants-1991_11
特許番号
US05063146

関連ノート

読み込み中…