2-Aminothiophenol → alpha-[[(2-Amino-phenyl)-thio]-methyl]-4-methoxy benzeneacetic acid
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[CH2:13])[C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.[NH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[SH:21]>C(O)C>[NH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[S:21][CH2:13][CH:9]([C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=1)[C:10]([OH:12])=[O:11]参加物
4
実験手順
A solution of 125 ml of ethanol, 8.9 g of 4-methoxy-α-methylene benzeneacetic acid and 5.35 ml of 2-amino thiophenol was refluxed for 7 hours. The ethanol was evaporated off and the residue was crystallized from 500 ml of isopropyl ether to obtain 11 g of the desired product melting at 118° C. and used as is for the following step.
後処理
- customThe ethanol was evaporated off
- customthe residue was crystallized from 500 ml of isopropyl ether
出典と根拠
- ORDレコード
- ord-d095d8bc044340b2b18fbd28e653b24d
- 出典データセット
- uspto-grants-1991_11
- 特許番号
- US05063225
反応ノート
読み込み中…