3,4-Diaminopyridine → HCID 178432317、化合物
反応式
[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[NH2:8].[C:9](OC(=O)C)(=O)[CH3:10]>>[CH3:9][C:10]1[NH:8][C:7]2[CH:6]=[CH:5][N:4]=[CH:3][C:2]=2[N:1]=1参加物
3
反応条件
- 温度
- 100 °C
実験手順
A mixture of 3,4-diaminopyridine (20.0 g, 183 mmol) and acetic anhydride (360 ml) was heated at 100° C. for 16 hours. The excess reagent was removed under reduced pressure, and the residue was purified by flash chromatography eluting with ethyl acetate:methanol, 3:1. The product was a brown solid, (15.5 g, 64%).
後処理
- customThe excess reagent was removed under reduced pressure
- customthe residue was purified by flash chromatography
- washeluting with ethyl acetate
出典と根拠
- ORDレコード
- ord-b736a05c55c3408ab390fa8dbe453720
- 出典データセット
- uspto-grants-1991_11
- 特許番号
- US05063237
反応ノート
読み込み中…