Ammonia → HCID 10265671、化合物

反応式

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[C:10](Cl)[N:9]=[C:8]2[NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[CH3:21].[NH3:22]>>[NH2:22][C:10]1[N:9]=[C:8]([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:21])[C:7]2[C:12](=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][CH:6]=2)[N:11]=1

参加物

反応物 2

HCID 222Ammonia

HCID 10086136HCID 10086136、化合物

生成物 1

HCID 10265671HCID 10265671、化合物収率 31%

実験手順

8-Methoxy-4-(2-methylphenylamino)-2-chloroquinazoline (1.8 g, 0.006 mol) was dissolved in ethanolic ammonia and heated in a sealed vessel at 120° for 3 hours. After cooling, removal of excess solvent and chromatography (silica gel, 2% methanolic ammonia in chloroform) the 2 amino-4-(2-methylphenylamino)-8-methoxyquinazoline was isolated as crystals (0.52 g, 31%) from ethanol, m.p. 218°-220°.

後処理

temperatureheated in a sealed vessel at 120° for 3 hours
temperatureAfter cooling
customremoval of excess solvent and chromatography (silica gel, 2% methanolic ammonia in chloroform) the 2 amino-4-(2-methylphenylamino)-8-methoxyquinazoline

出典と根拠

ORDレコード: ord-ef14af10347e42269a269838677330f6
出典データセット: uspto-grants-1991_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05064833

反応ノート

読み込み中…

参加物