Phosphorus oxychloride → 4-Chloroquinazolin-2-amine
反応式
[NH2:1][C:2]1[NH:11][C:10](=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.P(Cl)(Cl)([Cl:15])=O>>[NH2:1][C:2]1[N:11]=[C:10]([Cl:15])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1参加物
3
実験手順
2-Amino-4-(3H)-quinazolone (2.0 g, 0.0124 mol) was heated under reflux in phosphoryl chloride (19.02 g, 0.0124 mol) for 2.5 hours. The reaction mixture was partitioned between chloroform, ice and NaOH solution (pH 9) and the organic phase dried, filtered, excess solvent removed and the residue triturated with chloroform to give 2-amino-4-chloroquinazoline (0.42 g, 19%) m.p. 275°-278°.
後処理
- customThe reaction mixture was partitioned between chloroform, ice and NaOH solution (pH 9)
- customthe organic phase dried
- filtrationfiltered
- customexcess solvent removed
- customthe residue triturated with chloroform
出典と根拠
- ORDレコード
- ord-a00b58d881d04dd3ad21ea4e7e30bf0e
- 出典データセット
- uspto-grants-1991_11
- 特許番号
- US05064833
反応ノート
読み込み中…