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(2S,3S)-2-Chloro-3-methylvaleric Acid → p-[5-(2,6-Dimethylheptyl)-pyrimidin-2-yl]-phenyl (S,S)-3-methyl-2-chloropentanoate

HRID 973711
ノート
印刷プレビュー

反応式

HRID 973711 の反応式
[CH3:1][C@@H:2]([CH2:8][CH3:9])[C@H:3]([Cl:7])[C:4]([OH:6])=[O:5].[CH3:10][CH:11]([CH2:26][CH2:27][CH2:28][CH:29]([CH3:31])[CH3:30])[CH2:12][C:13]1[CH:14]=[N:15][C:16]([C:19]2[CH:24]=[CH:23][C:22](O)=[CH:21][CH:20]=2)=[N:17][CH:18]=1.C(OC(OCC)C(C[C@@H](C)CCCC(C)C)C(OCC)OCC)C>C(Cl)Cl>[CH3:1][C@@H:2]([CH2:8][CH3:9])[C@H:3]([Cl:7])[C:4]([O:6][C:22]1[CH:21]=[CH:20][C:19]([C:16]2[N:15]=[CH:14][C:13]([CH2:12][CH:11]([CH3:10])[CH2:26][CH2:27][CH2:28][CH:29]([CH3:31])[CH3:30])=[CH:18][N:17]=2)=[CH:24][CH:23]=1)=[O:5]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 11051847(2S,3S)-2-Chloro-3-methylvaleric AcidHCID 53766363(S)-1,1,3,3-tetraethoxy-2-(2,6-dimethylheptyl)-propaneHCID 136125432p-[5--(2,6-Dimethylheptyl)-pyrimidin-2-yl]phenol

生成物 1

HCID 57237993p-[5-(2,6-Dimethylheptyl)-pyrimidin-2-yl]-phenyl (S,S)-3-methyl-2-chloropentanoate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane
溶媒

実験手順

A mixture of 8 g of (S,S)-3-methyl-2-chloropentanoic acid, 16 g of optically active p-[5--(2,6-dimethylheptyl)-pyrimidin-2-yl]phenol [obtainable by condensation, known from the literature, of (S)-1,1,3,3-tetraethoxy-2-(2,6-dimethylheptyl)-propane with 4-hydroxyphenylamidine hydrochloride], 11.6 g of N,N-dicyclohexylcarbodiimide, 0.6 g of 4-N,N-dimethylaminopyridine and 300 ml of methylene chloride is stirred overnight at room temperature. After the urea derivative which has precipitated has been filtered off, the filtrate is washed with dilute hydrochloric acid and H2O and the organic phase is worked up in the customary manner. p-[5-(2,6-Dimethylheptyl)-pyrimidin-2-yl]-phenyl (S,S)-3-methyl-2-chloropentanoate is obtained.

後処理

  1. customobtainable by condensation
  2. customAfter the urea derivative which has precipitated
  3. filtrationhas been filtered off
  4. washthe filtrate is washed with dilute hydrochloric acid and H2O

出典と根拠

ORDレコード
ord-5bcee076aaf44e0693936ec57a8aa534
出典データセット
uspto-grants-1991_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05064569

反応ノート

読み込み中…

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