Dimethylformamide → HCID 178499052、化合物

反応式

C[C:2]([CH2:4][C:5]([O:7]CC)=O)=[S:3].[NH2:10][C:11]1[N:15]=[C:14]([C:16]([O:18][CH3:19])=[O:17])[NH:13][N:12]=1.[CH3:20]N(C)C=O>>[OH:7][C:5]1[CH:4]=[C:2]([S:3][CH3:20])[N:12]2[N:13]=[C:14]([C:16]([O:18][CH3:19])=[O:17])[N:15]=[C:11]2[N:10]=1

参加物

反応物 3

HCID 6228Dimethylformamide

HCID 77201methyl 5-amino-1H-(1,2,4)triazole-3-carboxylate

HCID 11744773Butanoic acid, 3-thioxo-, ethyl ester

生成物 1

HCID 178499052HCID 178499052、化合物

実験手順

A suspension of ethyl 2-methylthiocarbonylacetate (37.6 g) and 3-amino-5-methoxycarbonyl-s-triazole (20 g) in dimethylformamide (200 ml) was refluxed for one hour. After removing the solvent by distillation under reduced pressure, ether was added to the residue, and the formed crystals were purified by silica gel chromatography, giving 11.7 g of the objective compound.