Cortisol → HCID 178441396、化合物

反応式

[CH3:1][CH2:2][CH2:3][CH2:4][CH:5]1[C:40](=[O:41])[O:39][CH:38]([CH:42]([CH:44]([OH:52])[CH2:45][CH2:46][CH2:47][NH:48][C:49]([NH2:51])=[NH:50])[CH3:43])[CH:37]([CH3:53])[CH:36]=[C:35]([CH3:54])[CH2:34][CH2:33][CH2:32][CH2:31][CH:30]([OH:55])[CH2:29][CH:28]([OH:56])[CH2:27][CH:26]([OH:57])[CH2:25][CH:24]([OH:58])[CH2:23][CH:22]([OH:59])[CH:21]([O:60][C@H:61]2[O:65][C@H:64]([CH2:66][OH:67])[C@@H:63]([OH:68])[C@@H:62]2[OH:69])[CH:20]=[C:19]([CH3:70])[CH:18]([OH:71])[CH2:17][CH2:16][CH2:15][CH:14]([OH:72])[CH2:13][CH2:12][CH2:11][CH:10]([OH:73])[CH2:9][CH2:8][CH:7]([CH3:74])[CH:6]1[OH:75].[CH3:76][C@@H:77]1[C@@H:116]([OH:117])[C@@H:115]([CH3:118])[C@H:114]([CH3:119])[O:113][C:111](=[O:112])[CH2:110][C@H:109]([OH:120])[CH2:108][C@H:107]([OH:121])[CH2:106][C@H:105]([OH:122])[CH2:104][CH2:103][C@@H:102]([OH:123])[C@H:101]([OH:124])[CH2:100][C@@:98]2([OH:125])[O:99][C@H:94]([C@H:95]([C:127]([OH:129])=[O:128])[C@@H:96]([OH:126])[CH2:97]2)[CH2:93][C@@H:92]([O:130][C@H:131]2[O:136][C@@H:135]([CH3:137])[C@H:134]([OH:138])[C@@H:133]([NH2:139])[C@H:132]2[OH:140])[CH:91]=[CH:90][CH:89]=[CH:88][CH:87]=[CH:86][CH:85]=[CH:84][CH2:83][CH2:82][CH:81]=[CH:80][CH:79]=[CH:78]1.[CH3:141][C@@:142]12[C@H:152]3[C@@H:153]([OH:166])[CH2:154][C@:155]4([CH3:165])[C@@:159]([OH:164])([C:160]([CH2:162][OH:163])=[O:161])[CH2:158][CH2:157][C@H:156]4[C@@H:151]3[CH2:150][CH2:149][C:148]1=[CH:147][C:145](=[O:146])[CH2:144][CH2:143]2>>[CH3:1][CH2:2][CH2:3][CH2:4][CH:5]1[C:40](=[O:41])[O:39][CH:38]([CH:42]([CH:44]([OH:52])[CH2:45][CH2:46][CH2:47][NH:48][C:49]([NH2:51])=[NH:50])[CH3:43])[CH:37]([CH3:53])[CH:36]=[C:35]([CH3:54])[CH2:34][CH2:33][CH2:32][CH2:31][CH:30]([OH:55])[CH2:29][CH:28]([OH:56])[CH2:27][CH:26]([OH:57])[CH2:25][CH:24]([OH:58])[CH2:23][CH:22]([OH:59])[CH:21]([O:60][C@H:61]2[O:65][C@H:64]([CH2:66][OH:67])[C@@H:63]([OH:68])[C@@H:62]2[OH:69])[CH:20]=[C:19]([CH3:70])[CH:18]([OH:71])[CH2:17][CH2:16][CH2:15][CH:14]([OH:72])[CH2:13][CH2:12][CH2:11][CH:10]([OH:73])[CH2:9][CH2:8][CH:7]([CH3:74])[CH:6]1[OH:75].[CH3:141][C@@:142]12[C@H:152]3[C@@H:153]([OH:166])[CH2:154][C@:155]4([CH3:165])[C@@:159]([OH:164])([C:160]([CH2:162][OH:163])=[O:161])[CH2:158][CH2:157][C@H:156]4[C@@H:151]3[CH2:150][CH2:149][C:148]1=[CH:147][C:145](=[O:146])[CH2:144][CH2:143]2.[CH3:76][C@@H:77]1[C@@H:116]([OH:117])[C@@H:115]([CH3:118])[C@H:114]([CH3:119])[O:113][C:111](=[O:112])[CH2:110][C@H:109]([OH:120])[CH2:108][C@H:107]([OH:121])[CH2:106][C@H:105]([OH:122])[CH2:104][CH2:103][C@@H:102]([OH:123])[C@H:101]([OH:124])[CH2:100][C@@:98]2([OH:125])[O:99][C@H:94]([C@H:95]([C:127]([OH:129])=[O:128])[C@@H:96]([OH:126])[CH2:97]2)[CH2:93][C@@H:92]([O:130][C@H:131]2[O:136][C@@H:135]([CH3:137])[C@H:134]([OH:138])[C@@H:133]([NH2:139])[C@H:132]2[OH:140])[CH:91]=[CH:90][CH:89]=[CH:88][CH:87]=[CH:86][CH:85]=[CH:84][CH2:83][CH2:82][CH:81]=[CH:80][CH:79]=[CH:78]1

参加物

反応物 3

HCID 5754Cortisol

HCID 44424838Nystatin

HCID 178441392HCID 178441392、化合物

生成物 1

HCID 178441396HCID 178441396、化合物

実験手順

From 20 g of Primycin and 40.0 g of N-methyl-pyrrolidone-2 a gel is prepared at 70° C., whereupon nystatin and hydrocortisone are added at room temperature under constant stirring. A very viscous solution is obtained which becomes gelous on standing for 24 hours.

後処理

additionare added at room temperature under constant stirring
customA very viscous solution is obtained which

出典と根拠

ORDレコード: ord-b01e97983ae342f2a6a3246acefdddf6
出典データセット: uspto-grants-1991_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05064815

反応ノート

読み込み中…