Hydrochloric Acid → N-(4-dimethylamino-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide hydrochloride

HRID 973987ノート

反応式

HRID 973987 の反応式
[CH3:1][N:2]([CH3:24])[CH2:3][C:4]#[C:5][CH2:6][NH:7][C:8](=[O:23])[C:9]([CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)([OH:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[ClH:25]>CO>[ClH:25].[CH3:24][N:2]([CH3:1])[CH2:3][C:4]#[C:5][CH2:6][NH:7][C:8](=[O:23])[C:9]([CH:17]1[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]1)([OH:16])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 14931303N-(4-dimethylamino-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide

生成物 1

HCID 19775486N-(4-dimethylamino-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of N-(4-dimethylamino-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide 0.48 g) in methanol (5 ml) was added 6.4N methanolic hydrogen chloride (1.5 ml) and the solution was evaporated in vacuo. The oily residue was crystallized from a mixture of isopropyl alcohol and ethyl acetate to give N-(4-dimethylamino-2-butynyl)-2-cyclohexyl-2-hydroxy-2phenylacetamide hydrochloride (0.3 g).

後処理

  1. customthe solution was evaporated in vacuo
  2. customThe oily residue was crystallized from a mixture of isopropyl alcohol and ethyl acetate

出典と根拠

ORDレコード
ord-4fb0e42675e547e298bf7e343860ef6d
出典データセット
uspto-grants-1991_11
特許番号
US05066680

反応ノート

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