Phosgene → HCID 15675496、化合物
反応式
Cl.[CH2:2]([O:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH2:17])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[N-]=C=O.[C:21](Cl)(Cl)=[O:22].[CH3:25][NH:26][OH:27]>C1(C)C=CC=CC=1>[CH2:2]([O:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:21]([N:26]([OH:27])[CH3:25])=[O:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1参加物
6
実験手順
By the method of Example 32 above, 7-(benzyloxy)heptylamine hydrochloride was converted to the isocyanate by treatment with phosgene in toluene, and then treated with N-methylhydroxylamine. Chromatography on silica gel, and recrystallization from ethyl acetate-hexane, provided the title compound as a white solid, mp 69°-70.5° C.
後処理
- customChromatography on silica gel, and recrystallization from ethyl acetate-hexane
出典と根拠
- ORDレコード
- ord-47a9119d0381448eb0a23452aef9ea50
- 出典データセット
- uspto-grants-1991_11
- 特許番号
- US05066658
反応ノート
読み込み中…