Water → 1,4-Bisacetylamino-2-fluorobenzene

HRID 974143ノート

反応式

HRID 974143 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:11])[CH3:10])=[C:4]([F:12])[CH:3]=1.O.[C:14](OC(=O)C)(=[O:16])[CH3:15]>C(O)(=O)C>[C:9]([NH:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:14](=[O:16])[CH3:15])=[CH:3][C:4]=1[F:12])(=[O:11])[CH3:10]

参加物

5

反応物 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 255648n-(4-Amino-2-fluorophenyl)acetamide

生成物 1

HCID 148170801,4-Bisacetylamino-2-fluorobenzene

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
15 °C

実験手順

134.5 g (0.8 mol) of the 1-amino-4-acetylamino-3-fluorobenzene prepared above under A. are heated at 85° C. together with 800 ml of water and 34 g of acetic acid. 86.5 g of acetic anhydride are added to this mixture in the course of one hour. The reaction mixture is subsequently stirred at the same temperature for a further hour and cooled to 15° C. The product which has precipitated is then filtered off, washed twice with 150 ml of water each time and dried.

後処理

  1. customThe product which has precipitated
  2. filtrationis then filtered off
  3. washwashed twice with 150 ml of water each time
  4. customdried

出典と根拠

ORDレコード
ord-4acb91097a55474a9d82e95b0a27f20a
出典データセット
uspto-grants-1991_11
特許番号
US05067967

反応ノート

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