Benzene, 1-bromo-4-(trifluoromethyl)- → HCID 178444406、化合物

HRID 974159ノート

反応式

HRID 974159 の反応式
[CH2:1]([C@H:6]1[CH2:11][CH2:10][C@H:9]([C:12]#[CH:13])[CH2:8][CH2:7]1)[CH2:2][CH2:3][CH2:4][CH3:5].[F:14][C:15]([F:24])([F:23])[C:16]1[CH:21]=[CH:20][C:19](Br)=[CH:18][CH:17]=1>[Cu]I.C(N(CC)CC)C>[CH2:1]([C@H:6]1[CH2:7][CH2:8][C@H:9]([C:12]#[C:13][C:19]2[CH:20]=[CH:21][C:16]([C:15]([F:24])([F:23])[F:14])=[CH:17][CH:18]=2)[CH2:10][CH2:11]1)[CH2:2][CH2:3][CH2:4][CH3:5]

参加物

5

反応物 2

HCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-HCID 178455744HCID 178455744、化合物

生成物 1

HCID 178444406HCID 178444406、化合物

試薬・触媒・溶媒 2

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)触媒HCID 8471Triethylamine溶媒

実験手順

A mixture of 0.06 mol of trans-4-pentylcyclohexylacetylene, 0.06 mol of 4-trifluoromethyl-bromobenzene, 250 ml of triethylamine, 1.2 mmol of Pd(II) catalyst and 0.6 mmol of CuI is stirred at room temperature for 15 hours. The reaction mixture is diluted with petroleum ether and filtered. Evaporation and purification give 1-(trans-4-pentylcyclohexyl)-2-(4-trifluoromethylphenyl)acetylene of M.=43°.

後処理

  1. filtrationfiltered
  2. customEvaporation and purification

出典と根拠

ORDレコード
ord-a7ae0d83fe734c668005c4a7a79eb028
出典データセット
uspto-grants-1991_11
特許番号
US05068053

反応ノート

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