Methyl piperidine-3-carboxylate → HCID 15017107、化合物

HRID 974163ノート

反応式

HRID 974163 の反応式
[P:1](=[O:9])([N:6]=[C:7]=[O:8])([S:4][CH3:5])[O:2][CH3:3].[NH:10]1[CH2:15][CH2:14][CH2:13][CH:12]([C:16]([O:18][CH3:19])=[O:17])[CH2:11]1>CCOCC>[CH3:3][O:2][P:1]([NH:6][C:7]([N:10]1[CH2:15][CH2:14][CH2:13][CH:12]([C:16]([O:18][CH3:19])=[O:17])[CH2:11]1)=[O:8])([S:4][CH3:5])=[O:9]

参加物

4

反応物 2

HCID 351626Methyl piperidine-3-carboxylateHCID 14879948O,S-dimethyl phosphoroisocyanatidothioate

生成物 1

HCID 15017107HCID 15017107、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A solution of 8.36 g of O,S-dimethyl phosphoroisocyanatidothioate in 100 ml of ether was cooled to 0° C. and to it was added dropwise with stirring 7.15 g of methyl 3-piperidinecarboxylate. The mixture was allowed to warm to ambient temperature and react overnight. The precipitate that formed was collected by filtration, extracted with ether, and dried under reduced pressure to obtain 11.5 g (74 percent of theory) of the title compound as white crystals melting at 65°-67° C.

後処理

  1. additionwas added dropwise
  2. customreact overnight
  3. customThe precipitate that formed
  4. filtrationwas collected by filtration
  5. extractionextracted with ether
  6. customdried under reduced pressure

出典と根拠

ORDレコード
ord-f4959952b8fe4e2482533db7d8143e92
出典データセット
uspto-grants-1991_11
特許番号
US05068230

反応ノート

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