Potassium Carbonate → Tert-butyl 4-ethynylbenzoate

HRID 974208ノート

反応式

HRID 974208 の反応式
[C:1]([O:5][C:6](=[O:19])[C:7]1[CH:12]=[CH:11][C:10]([C:13]#[C:14][Si](C)(C)C)=[CH:9][CH:8]=1)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[C:1]([O:5][C:6](=[O:19])[C:7]1[CH:8]=[CH:9][C:10]([C:13]#[CH:14])=[CH:11][CH:12]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 13965007tert-Butyl 4-((trimethylsilyl)ethynyl)benzoate

生成物 1

HCID 13965008Tert-butyl 4-ethynylbenzoate収率 95.9%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

274.4 g of 4-(trimethylsilylethinyl)-benzoic acid tert.-butyl ester and 12.5 g of anhydrous potassium carbonate in 1.5 l of absolute methanol are stirred together for 3 hours under nitrogen. The reaction mixture is then concentrated by evaporation and worked up with CH2Cl2 /H2O to yield 194 g of 4-ethinyl-benzoic acid tert.-butyl ester.

後処理

  1. concentrationThe reaction mixture is then concentrated by evaporation

出典と根拠

ORDレコード
ord-39fd856448a04295a5c1912c3375a7ac
出典データセット
uspto-grants-1991_11
特許番号
US05068300

反応ノート

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