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Potassium Carbonate → 2-Amino-6-(1H-inden-2-yl-methyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepine | HCID 19985785 | — |
| 反応物 | 2-chloromethyl-1H-indene | HCID 19985793 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-Amino-6-(1H-inden-2-yl-methyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine | HCID 19985975 | 4% |
反応手順
Prepared from 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine, potassium carbonate and 2-chloromethyl-1H-indene (prepared from 1H-indene, paraformaldehyde and concentrated hydrochloric acid) in anhydrous dimethylformamide for 2 hours at 50° C. Yield: 4% of theory, Melting point: 134°-138° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05068325 |
| 出典データセット | uspto-grants-1991_11 |
| ORD ID | ord-f628993a88a54087b8da7eda00a08319 |
| 出典メモ | uspto-grants-1991_11 |