化工社化工社 化学情報印刷レポート · 研究参考用
2-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepine → 2-Amino-6-(4-phenyl-3-buten-1-yl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepine | HCID 19985785 | — |
| 反応物 | Toluene trichloromethane | HCID 22987606 | — |
| 反応物 | (4-Bromo-1-buten-1-yl)benzene | HCID 54504166 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 2-Amino-6-(4-phenyl-3-buten-1-yl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine | HCID 73668874 | 39% |
反応手順
Prepared analogously to Example 8 from 4-phenyl-3-buten-1-yl-bromide [boiling point 93° C./1,5 torr; prepared from 1-cyclopropyl-1-phenyl-carbinol with phosphorous tribromide] with 4 equivalents of 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine in pure chloroform during 8 hours at 60° C. Yield: 39% of theory, Melting point: 157°-158° C. (chloroform/toluene)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05068325 |
| 出典データセット | uspto-grants-1991_11 |
| ORD ID | ord-8898850d1f58481ca25678d839724852 |
| 出典メモ | uspto-grants-1991_11 |