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O-Xylene → N-[3-(3,5-di-t-butyl-4-hydroxyphenyl)propanamido]-4-methylhexahydrophthalimide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | O-Xylene | HCID 7237 | — |
| 反応物 | 3,5-Di-tert-butyl-4-hydroxyhydrocinnamic acid hydrazide | HCID 64865 | — |
| 反応物 | Hexahydro-4-methylphthalic anhydride | HCID 86876 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-[3-(3,5-di-t-butyl-4-hydroxyphenyl)propanamido]-4-methylhexahydrophthalimide | HCID 19902401 | 100.5% |
反応手順
A mixture of 4-methylhexahydrophthalic anhydride (32.8 g, 200 mmol), 3-(3,5-di-t-butyl-4-hydroxyphenyl)propanoic acid hydrazide (58.4 g, 200 mmol) and 650 ml of xylene was refluxed for 90 minutes under a nitrogen atmosphere with the azeotropic removal of water. The solvent was removed on a rotary evaporator to afford approximately 89 g of a white solid having a melting range of 87°-92° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05068356 |
| 出典データセット | uspto-grants-1991_11 |
| ORD ID | ord-a07343b029b64fe6bbdc278a4e0cf9f4 |
| 出典メモ | uspto-grants-1991_11 |