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HRID 974397作成日：2026年10月26日

2,4-Dimethoxytetrahydrofuran → 1-[3-(2,4-Difluorophenyl)propyl]-1H-pyrrole

https://huagongshe.com/reaction/974397

反応式

関与物質

役割名称HCID仕込み量
反応物2,4-DimethoxytetrahydrofuranHCID 19986368—
反応物2,4-Difluoro-benzenepropanamineHCID 22669139—
生成物1-[3-(2,4-Difluorophenyl)propyl]-1H-pyrroleHCID 19986371—

反応手順

17.1 g (0.10 mol) of 3-(2,4-difluorophenyl)propylamine are heated at 260° C. for 2 hours in an autoclave with 13.2 g (0.10 mol) of 2,4-dimethoxytetrahydrofuran. The reaction mixture is cooled and then purified by vacuum distillation. 10.6 g (48% of theory) of a colourless oil which boils at 80° C. and 0.2 mbar or 146°-147° C. and 15 mbar are obtained.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05068371
出典データセットuspto-grants-1991_11
ORD IDord-54f1e1a3b3494f0d8649e77445d4fe39
出典メモuspto-grants-1991_11