Potassium Carbonate → HCID 54346962、化合物
反応式
Cl[CH2:2][C:3]([CH3:17])([CH3:16])[C:4]([NH:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=1[F:15])=[O:5].C(=O)([O-])[O-].[K+].[K+]>C(C(C)=O)C>[CH3:2][C:3]1([CH3:17])[CH2:16][N:6]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=2[F:15])[C:4]1=[O:5]参加物
4
反応条件
- 温度
- 75 °C
実験手順
49.7 g (0.19 mol) of 3-chloro-2,2-dimethyl-N-[(2,4-difluorophenyl)methyl]propanamide and 78.8 g (0.57 mol) of potassium carbonate are suspended in 200 ml of methyl ethyl ketone, and the suspension is warmed and stirred at 75° C. for 24 hours. When the reaction is complete (GC check), the mixture is filtered, and the filtrate is evaporated on a vacuum rotary evaporator. 40.9 g (95% of theory) of a yellow oil are obtained.
後処理
- temperaturethe suspension is warmed
- filtrationthe mixture is filtered
- customthe filtrate is evaporated on a vacuum rotary evaporator
- custom40.9 g (95% of theory) of a yellow oil are obtained
出典と根拠
- ORDレコード
- ord-3a4addd6971d49d5955b43b04fb7c208
- 出典データセット
- uspto-grants-1991_11
- 特許番号
- US05068371
反応ノート
読み込み中…