3-Chloropropionitrile → HCID 178511037、化合物

HRID 974428ノート

反応式

HRID 974428 の反応式
[S:1]([NH2:5])([NH2:4])(=[O:3])=[O:2].Cl[C:7]1[CH:12]=[C:11]([Cl:13])[CH:10]=[C:9]([Cl:14])[C:8]=1[S:15]([OH:18])(=[O:17])=[O:16].[Cl:19][CH2:20][CH2:21][C:22]#[N:23]>C(Cl)Cl.CC(C)=O>[Cl:14][C:9]1[CH:10]=[C:11]([Cl:13])[C:12]([Cl:19])=[CH:7][C:8]=1[S:15]([OH:18])(=[O:17])=[O:16].[S:1]([NH:5][C:22](=[NH:23])[CH2:21][CH2:20][Cl:19])(=[O:3])(=[O:2])[NH2:4]

参加物

6

反応物 3

HCID 109633-ChloropropionitrileHCID 82267SulfamideHCID 1286712,4,6-Trichlorobenzenesulfonate

生成物 1

HCID 178511037HCID 178511037、化合物

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 6344Dichloromethane溶媒

反応条件

温度
57.5 °C

実験手順

Sulfamide (9.6 g, 0.1 mole) was added to a solution of 2,4,6-trichlorobenzenesulfonic acid (52.2 g, 0.2 mole) in 3-chloropropionitrile (51.3 g, 0.6 mole). The suspension was heated at 55-60° C., for 18 hours. At the end of the heating period, the mixture was cooled to room temperature, diluted with methylene chloride (150 ml), and filtered. The solid, thus obtained, was suspended in acetone (50 ml) and the suspension filtered and the product dried.

後処理

  1. temperatureAt the end of the heating period, the mixture was cooled to room temperature
  2. filtrationfiltered
  3. customThe solid, thus obtained
  4. filtrationthe suspension filtered
  5. customthe product dried

出典と根拠

ORDレコード
ord-286eded3fc4740119c3ad4ed69bbb3ea
出典データセット
uspto-grants-1991_11
特許番号
US05068405

反応ノート

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