Water → Meridia

HRID 974526ノート

反応式

HRID 974526 の反応式
Cl.[CH3:2][N:3]([CH:5]([C:10]1([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[CH2:13][CH2:12][CH2:11]1)[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:4].[OH2:21]>>[OH2:21].[ClH:20].[CH3:2][N:3]([CH:5]([C:10]1([C:14]2[CH:15]=[CH:16][C:17]([Cl:20])=[CH:18][CH:19]=2)[CH2:13][CH2:12][CH2:11]1)[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:4]

参加物

3

反応物 2

HCID 962WaterHCID 64764Sibutramine Hydrochloride

生成物 1

HCID 64765Meridia

実験手順

N,N-Dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride (0.5 g) was dissolved in boiling water (5 ml). The solution was filtered whilst hot and the filtrate cooled. The product crystallised from the cooled filtrate and was collected by filtration and dried in vacuo at ambient temperature to give N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate (m.p. 193°-195.5° C.).

後処理

  1. filtrationThe solution was filtered whilst hot and the filtrate
  2. temperaturecooled
  3. customThe product crystallised from the cooled filtrate
  4. filtrationwas collected by filtration
  5. customdried in vacuo at ambient temperature

出典と根拠

ORDレコード
ord-8f3d69582a36464cbd362df969a55365
出典データセット
uspto-grants-1991_11
特許番号
US05068440

反応ノート

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