Water → Meridia

HRID 974527ノート

反応式

HRID 974527 の反応式
Cl.[CH3:2][N:3]([CH:5]([C:10]1([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[CH2:13][CH2:12][CH2:11]1)[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:4].[OH2:21]>C1(C)C=CC=CC=1>[OH2:21].[ClH:20].[CH3:2][N:3]([CH:5]([C:10]1([C:14]2[CH:15]=[CH:16][C:17]([Cl:20])=[CH:18][CH:19]=2)[CH2:13][CH2:12][CH2:11]1)[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:4]

参加物

4

反応物 2

HCID 962WaterHCID 64764Sibutramine Hydrochloride

生成物 1

HCID 64765Meridia

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

N,N-Dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride (5 g) was dissolved in a boiling mixture of toluene (126 ml) and water (12.6 ml). The solution was filtered whilst hot and the filtrate cooled. The product crystallised from the cooled filtrate and was collected by filtration and dried in vacuo at ambient temperature to give N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate (m.p. 194°-196° C.).

後処理

  1. filtrationThe solution was filtered whilst hot and the filtrate
  2. temperaturecooled
  3. customThe product crystallised from the cooled filtrate
  4. filtrationwas collected by filtration
  5. customdried in vacuo at ambient temperature

出典と根拠

ORDレコード
ord-eada22b79e60499c897fdf45035a69b7
出典データセット
uspto-grants-1991_11
特許番号
US05068440

反応ノート

読み込み中…