Acetone → Meridia

HRID 974528ノート

反応式

HRID 974528 の反応式
Cl.[CH3:2][N:3]([CH:5]([C:10]1([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[CH2:13][CH2:12][CH2:11]1)[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:4].CC(C)=[O:23]>O>[OH2:23].[ClH:20].[CH3:2][N:3]([CH:5]([C:10]1([C:14]2[CH:15]=[CH:16][C:17]([Cl:20])=[CH:18][CH:19]=2)[CH2:13][CH2:12][CH2:11]1)[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:4]

参加物

4

反応物 2

HCID 180AcetoneHCID 64764Sibutramine Hydrochloride

生成物 1

HCID 64765Meridia

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

N,N-Dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride (10 g) was dissolved in a boiling mixture of acetone (110 ml) and water (1.2 ml). The solution was filtered whilst hot and the volume of the filtrate reduced by the removal by distillation of 80 ml of solvent. The product was collected from the cooled concentrate by filtration and dried in vacuo at ambient temperature to give N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate (m.p. 195° C.).

後処理

  1. filtrationThe solution was filtered whilst hot and the volume of the filtrate
  2. customreduced by the removal by distillation of 80 ml of solvent
  3. customThe product was collected from the cooled
  4. concentrationconcentrate by filtration
  5. customdried in vacuo at ambient temperature

出典と根拠

ORDレコード
ord-99c3114c5f71476ea11f27980dc46c35
出典データセット
uspto-grants-1991_11
特許番号
US05068440

反応ノート

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