Water → Meridia

HRID 974529ノート

反応式

HRID 974529 の反応式
Cl.[CH3:2][N:3]([CH:5]([C:10]1([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[CH2:13][CH2:12][CH2:11]1)[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:4].[OH2:21]>>[OH2:21].[ClH:20].[CH3:2][N:3]([CH:5]([C:10]1([C:14]2[CH:15]=[CH:16][C:17]([Cl:20])=[CH:18][CH:19]=2)[CH2:13][CH2:12][CH2:11]1)[CH2:6][CH:7]([CH3:9])[CH3:8])[CH3:4]

参加物

3

反応物 2

HCID 962WaterHCID 64764Sibutramine Hydrochloride

生成物 1

HCID 64765Meridia

実験手順

A sample (1 g) of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride which had been dehydrated in vacuo at 70° C. for 7 hours was dissolved in a boiling mixture of water (0.5 ml) and an organic solvent (4.5 ml). The solution was allowed to cool to ambient temperature and then stored at 4° C. for three hours. A solid was collected by filtration, washed with the organic solvent and dried in vacuo at ambient temperature for 18 hours to give N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate the melting point of which is given below.

後処理

  1. filtrationA solid was collected by filtration
  2. washwashed with the organic solvent
  3. customdried in vacuo at ambient temperature for 18 hours

出典と根拠

ORDレコード
ord-9de75bd130cd45eda8d7a7840f5de423
出典データセット
uspto-grants-1991_11
特許番号
US05068440

反応ノート

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