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Potassium Carbonate → 3-(2,4,6-Triiodophenoxy)nonane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2,4,6-Triiodophenol | HCID 11862 | — |
| 反応物 | 3-Nonanol | HCID 12216 | — |
| 反応物 | Methanesulfonate | HCID 85257 | — |
| 反応物 | 2-(2,4,6-Triiodophenoxy)pentadecane | HCID 15343309 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-(2,4,6-Triiodophenoxy)nonane | HCID 19959848 | 67.3% |
反応手順
The mesylate of 3-nonanol (11.5 g, 51.9 mmol), triiodophenol (24.5 g, 51.9 mmol) and potassium carbonate (7.18 g, 51.9 mmol) were reacted in dry DMF (200 ml) as per 2-(2,4,6-triiodophenoxy)-pentadecane except at an oil bath temperature of 87° C. for 16 hrs. The reaction was processed as for 2-(2,4,6-triiodophenoxy)-pentadecane to provide a light brown oil. Flash column chromatography (silica, hexanes) provided 3-(2,4,6-Triiodophenoxy)nonane (20.9 g, 67%) as a clear viscous oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05607660 |
| 出典データセット | uspto-grants-1997_03 |
| ORD ID | ord-8adec65c75924675a88dbe9001da7693 |
| 出典メモ | uspto-grants-1997_03 |