Acetic Acid → HCID 54371093、化合物
反応式
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH2:5][CH2:6][C:7]2=[O:12].[S:13]1[CH:17]=[CH:16][CH:15]=[C:14]1[CH:18]=O.N1CCCCC1.C(O)(=O)C>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH2:5][C:6](=[CH:18][C:14]1[S:13][CH:17]=[CH:16][CH:15]=1)[C:7]2=[O:12]参加物
6
反応条件
- 温度
- 130 °C
実験手順
To 4-methoxy-1-indanone (0.1 g; 0.62 mmol) were added thiophene-2-carboxaldehyde (87.5 μl ; 0.93 mmol), piperidine (18.5 μl ; 0.18 mmol) and acetic acid (10.7 μl ; 0.18 mmol). After heating at 130° C. for 90 minutes the mixture was taken up in CH2Cl2, washed with water and purified by flash chromatography, eluting with petroleum ether/ethyl acetate (95/5) to give 4-methoxy-2-(2-thienylmethylene)-1-indanone (140 mg; 90%).
後処理
- washwashed with water
- custompurified by flash chromatography
- washeluting with petroleum ether/ethyl acetate (95/5)
出典と根拠
- ORDレコード
- ord-5d261c75f25f4b1a9cc61a7ea2abca42
- 出典データセット
- uspto-grants-1997_03
- 特許番号
- US05607928
反応ノート
読み込み中…