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HCID 178418361、化合物 → Tetrahydro-6-(phenylmethyl)-1H-pyrrolo(3,4-b)pyridine-5,7(2H,6H)-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 反応物 | HCID 178524453 | HCID 178524453 | — |
| 触媒 | Ruthenium | HCID 23950 | — |
| 溶媒 | 2-Methoxyethanol | HCID 8019 | — |
| 生成物 | Tetrahydro-6-(phenylmethyl)-1H-pyrrolo(3,4-b)pyridine-5,7(2H,6H)-dione | HCID 9899604 | 90.1% |
反応手順
47.6 g (0.2 mol) of pyridine-2,3-dicarboxylic acid N-benzylimide (British Patent 1,086,637; Chem. Abstr. 68, 95695w) are hydrogenated in 400 ml of glycol monomethyl ether over 15 g of ruthenium-on-active charcoal (5% strength) at 90° C. under 100 bar until the calculated amount of hydrogen has been taken up. The catalyst is then filtered off and the filtrate is concentrated on a rotary evaporator. 44 g of an oily crude product are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05607942 |
| 出典データセット | uspto-grants-1997_03 |
| ORD ID | ord-2843ce7880d846f0928fc66e8164ab5a |
| 出典メモ | uspto-grants-1997_03 |