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Ethyl chloroformate → N-(1,1-dimethoxyprop-2-yl)urethane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl chloroformate | HCID 10928 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2,2-Dimethoxy-1-methylethylamine | HCID 93658 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N-(1,1-dimethoxyprop-2-yl)urethane | HCID 15069987 | — |
反応手順
80 g (0.73 mol) of ethyl chloroformate are added dropwise to 86.2 g (0.72 mol) of 2-aminopropionaldehyde dimethyl acetal in 350 ml of toluene and 32 g (0.8 mol) of NaOH in 300 ml of water. The mixture is stirred at room temperature for a further 2 hours, the organic phase is separated off, the aqueous phase is extracted with toluene and the toluene solutions are dried over K2CO3. The solution is concentrated and the residue is distilled.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05607942 |
| 出典データセット | uspto-grants-1997_03 |
| ORD ID | ord-8168b6ff1ef041fb9cd3b7b6c0230015 |
| 出典メモ | uspto-grants-1997_03 |