8-Chloro-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 8-Chloro-1-cyclopropyl-7-(trans-3-ethylamino-4-methylthio-1-pyrrolidinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

HRID 974946

反応式

HRID 974946 の反応式
[CH2:1]([NH:3][C@H:4]1[C@H:8]([S:9][CH3:10])[CH2:7][NH:6][CH2:5]1)[CH3:2].[Cl:11][C:12]1[C:13](F)=[C:14]([F:29])[CH:15]=[C:16]2[C:21]=1[N:20]([CH:22]1[CH2:24][CH2:23]1)[CH:19]=[C:18]([C:25]([OH:27])=[O:26])[C:17]2=[O:28]>>[Cl:11][C:12]1[C:13]([N:6]2[CH2:7][C@@H:8]([S:9][CH3:10])[C@H:4]([NH:3][CH2:1][CH3:2])[CH2:5]2)=[C:14]([F:29])[CH:15]=[C:16]2[C:21]=1[N:20]([CH:22]1[CH2:24][CH2:23]1)[CH:19]=[C:18]([C:25]([OH:27])=[O:26])[C:17]2=[O:28]

参加物

3

反応物 2

HCID 98359418-Chloro-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 15069979trans-3-Ethylamino-4-methylthio-pyrrolidine

生成物 1

HCID 150700828-Chloro-1-cyclopropyl-7-(trans-3-ethylamino-4-methylthio-1-pyrrolidinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

実験手順

The reaction is carried out analogously to Example 13 with trans-3-ethylamino-4-methylthio-pyrrolidine and 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid to give 8-chloro-1-cyclopropyl-7-(trans-3-ethylamino-4-methylthio-1-pyrrolidinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, melting points 217°-218° C. (with decomposition).

出典と根拠

ORDレコード
ord-03d694544e1848199a3433401cb5ae6d
出典データセット
uspto-grants-1997_03
特許番号
US05607942

関連ノート

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