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Pyridine → N-Methoxy-N,4-dimethyloxazole-5-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 4-Methyloxazole-5-carbonyl chloride | HCID 2795217 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | N-Methoxy-N,4-dimethyloxazole-5-carboxamide | HCID 18925369 | — |
反応手順
4-Methyl-5-oxazolecarbonyl chloride (15 g) and N,O-dimethylhydroxylamine hydrochloride (11 g) in dry chloroform (100 ml) were cooled to 0° C. and dry pyridine (28.5 g) was added. The mixture was allowed to warm to room temperature. After 30 minutes aqueous sodium hydrogen carbonate was added and the organic layer separated. The aqueous layer was extracted with dichloromethane. The combined organic layers were washed, dried and evaporated. The residue was purified by flash chromatography to yield the title compound as a white solid. M.p. 59°-60° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05607956 |
| 出典データセット | uspto-grants-1997_03 |
| ORD ID | ord-5e7672e863b54b3087d06ae6fbf739fb |
| 出典メモ | uspto-grants-1997_03 |