Ethanol → 1-(3-Furyl)-1-(4-methyl-5-oxazolyl)ethanol

HRID 975047

反応式

HRID 975047 の反応式
[CH3:1][C:2]1[N:3]=[CH:4][O:5][C:6]=1[C:7]([C:9]1[CH:13]=[CH:12][O:11][CH:10]=1)=[O:8].C[Li].[CH2:16](O)C.[Cl-].[Na+]>C(OCC)C>[O:11]1[CH:12]=[CH:13][C:9]([C:7]([C:6]2[O:5][CH:4]=[N:3][C:2]=2[CH3:1])([OH:8])[CH3:16])=[CH:10]1

参加物

6

反応物 4

HCID 702EthanolHCID 5234Sodium ChlorideHCID 189363073-Furyl 4-Methyl-5-oxazolyl KetoneHCID 178418348HCID 178418348、化合物

生成物 1

HCID 97941531-(3-Furyl)-1-(4-methyl-5-oxazolyl)ethanol

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

3-Furyl 4-methyl-5-oxazolyl ketone (1 g) in dry diethylether (15 ml) at -70° C. under a nitrogen atmosphere was treated dropwise with methyllithium (1.5M solution in diethylether, 4.1 ml). After 45 minutes the reaction mixture was allowed to warm to room temperature and ethanol (2 ml) was added. The mixture was poured into saturated aqueous sodium chloride and extracted with dichloromethane. Chromatography and crystallisation then gave 1-(3-furyl)-1-(4-methyl-5-oxazolyl)ethanol identical to the material obtained in (a) above.

後処理

  1. extractionextracted with dichloromethane
  2. customChromatography and crystallisation

出典と根拠

ORDレコード
ord-74524d204b7e49309002d4e65c9bb569
出典データセット
uspto-grants-1997_03
特許番号
US05607956

関連ノート

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