Water → 1-(3-Furyl)-1-(4-methyl-5-thiazolyl)ethanol

HRID 975050

反応式

HRID 975050 の反応式
Br[C:2]1[CH:6]=[CH:5][O:4][CH:3]=1.C([Li])CCC.[C:12]([C:15]1[S:19][CH:18]=[N:17][C:16]=1[CH3:20])(=[O:14])[CH3:13].O>C(OCC)C>[O:4]1[CH:5]=[CH:6][C:2]([C:12]([C:15]2[S:19][CH:18]=[N:17][C:16]=2[CH3:20])([OH:14])[CH3:13])=[CH:3]1

参加物

6

反応物 4

HCID 962WaterHCID 891643-BromofuranHCID 1622925-Acetyl-4-methylthiazoleHCID 178418339Butyllithium

生成物 1

HCID 189363091-(3-Furyl)-1-(4-methyl-5-thiazolyl)ethanol

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒3 回

実験手順

3-Bromofuran (6.8 g) in diethylether (15 ml) was added dropwise to n-butyllithium (2.5M solution in hexane, 18.4 ml) in diethylether (20 ml) at -70° C. under a nitrogen atmosphere. After 1 hour, 5-acetyl-4-methylthiazole (5 g) in diethylether (15 ml) was added dropwise. After a further 3 hours at -70° C., the mixture was allowed to warm to room temperature and was then left overnight. The mixture was poured into water and extracted with diethylether. The product thus obtained was crystallised from diethylether, m.p. 102°-104° C.

後処理

  1. waitAfter a further 3 hours at -70° C.
  2. waitwas then left overnight
  3. extractionextracted with diethylether
  4. customThe product thus obtained
  5. customwas crystallised from diethylether, m.p. 102°-104° C.

出典と根拠

ORDレコード
ord-bdf4f3d7eef34a679bd9eae33bcbd244
出典データセット
uspto-grants-1997_03
特許番号
US05607956

関連ノート

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