2-Acetylbenzofuran → 1-(2-Benzofuranyl)-1-(4-methyl-5-thiazolyl)ethanol

HRID 975071

反応式

HRID 975071 の反応式
C([Li])CCC.[CH3:6][C:7]1[N:8]=[C:9]([Si](C)(C)C)[S:10][CH:11]=1.[C:16]([C:19]1[O:20][C:21]2[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=2[CH:23]=1)(=[O:18])[CH3:17]>C(OCC)C>[O:20]1[C:21]2[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=2[CH:23]=[C:19]1[C:16]([C:11]1[S:10][CH:9]=[N:8][C:7]=1[CH3:6])([OH:18])[CH3:17]

参加物

5

反応物 3

HCID 154352-AcetylbenzofuranHCID 116583544-Methyl-2-trimethylsilylthiazoleHCID 178418339Butyllithium

生成物 1

HCID 189363601-(2-Benzofuranyl)-1-(4-methyl-5-thiazolyl)ethanol

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

n-Butyllithium (2.5M solution in hexane, 1 equivalent) was added dropwise to a solution of 4-methyl-2-trimethylsilylthiazole (1 equivalent) in dry diethyl ether at -70° C. under an atmosphere of dry nitrogen. After 30 minutes, 2-acetylbenzofuran (1 equivalent) in diethyl ether was added. After 1 hour the mixture was allowed to warm to room temperature and was then quenched by the addition of saturated aqueous sodium hydrogen carbonate. Work up in the normal fashion and column chromatography on silica gel then afforded the title compound.

後処理

  1. waitAfter 1 hour the mixture was allowed
  2. customwas then quenched by the addition of saturated aqueous sodium hydrogen carbonate

出典と根拠

ORDレコード
ord-88731ae77d054933bd9f358b10a06bda
出典データセット
uspto-grants-1997_03
特許番号
US05607956

関連ノート

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