関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 6-(Methoxycarbonyl)pyridine-3-carboxylic acid | HCID 579631 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 5-Chlorocarbonyl-pyridine-2-carboxylic acid methyl ester | HCID 15121177 | — |
反応手順
14.5 g (80 mmol) of 2-methoxycarbonylpyridine-5-carboxylic acid are treated with 6.48 ml of thionyl chloride and 2 ml of anhydrous N,N-dimethylformamide in 200 ml of anhydrous toluene. The mixture is heated at 70° C. for 3 h with stirring. It is then concentrated in vacuo and the residue is dissolved in 150 ml of tetrahydrofuran.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05607954 |
|---|
| 出典データセット | uspto-grants-1997_03 |
|---|
| ORD ID | ord-b7ff8f5cd07e44dab300a97985b59738 |
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| 出典メモ | uspto-grants-1997_03 |
|---|
