反応式
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([OH:13])=O)=[CH:7][N:6]=1)=[O:4].S(Cl)([Cl:16])=O.CN(C)C=O>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([Cl:16])=[O:13])=[CH:7][N:6]=1)=[O:4]参加物
5
反応条件
- 温度
- 70 °C
実験手順
14.5 g (80 mmol) of 2-methoxycarbonylpyridine-5-carboxylic acid are treated with 6.48 ml of thionyl chloride and 2 ml of anhydrous N,N-dimethylformamide in 200 ml of anhydrous toluene. The mixture is heated at 70° C. for 3 h with stirring. It is then concentrated in vacuo and the residue is dissolved in 150 ml of tetrahydrofuran.
後処理
- concentrationIt is then concentrated in vacuo
- dissolutionthe residue is dissolved in 150 ml of tetrahydrofuran
出典と根拠
- ORDレコード
- ord-b7ff8f5cd07e44dab300a97985b59738
- 出典データセット
- uspto-grants-1997_03
- 特許番号
- US05607954
関連ノート
読み込み中…