Hydrochloric Acid → 2-[(3-Chloro-3-methyl-2-nitrosobutoxy)methyl]-5-nitrofuran
反応式
[ClH:1].[N:2]([O:4]CCC(C)C)=O.[CH3:10][C:11]([CH3:24])=[CH:12][CH2:13][O:14][CH2:15][C:16]1[O:17][C:18]([N+:21]([O-:23])=[O:22])=[CH:19][CH:20]=1>>[Cl:1][C:11]([CH3:24])([CH3:10])[CH:12]([N:2]=[O:4])[CH2:13][O:14][CH2:15][C:16]1[O:17][C:18]([N+:21]([O-:23])=[O:22])=[CH:19][CH:20]=1参加物
4
反応条件
- 温度
- 5 °C
実験手順
Concentrated HCl (2.5 mL) was added to a cooled (0°-5° C.) solution of isoamyl nitrite (14.0 g, 0.12 mol) and 2-[[(3-methyl-2-butenyl)oxy]methyl]-5-nitrofuran (4.0 g, 0.06 mol). The temperature was maintained below 5° C. during the addition and the reaction mixture was stirred at 5° C. for an additional 30 min. The product was filtered and washed with a cold (-20° C.) 1:1 mixture of ethanol and ether. The solid was further washed with ether to afford a light yellow solid. Yield 2.6 g (52%). mp 134°-135° C.