HCID 19968441、化合物 → HCID 10220867、化合物

HRID 975828ノート

反応式

HRID 975828 の反応式
S(O)(O)(=O)=O.[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:18]3([CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[NH:17][CH2:16][CH2:15][CH:14]=2)=[CH:9][CH:8]=1>O>[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:18]3([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[NH:17][CH2:16][CH2:15][CH:14]=2)=[CH:9][CH:8]=1

参加物

3

反応物 1

HCID 19968441HCID 19968441、化合物

生成物 1

HCID 10220867HCID 10220867、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A mixture of 5-(4-chlorophenyl)-1-azaspiro[5.5]undec-4-ene sulphate (0.5 g, prepared as described in Example 5) and water (5 ml) was stirred at ambient temperature to give, initially, a mobile suspension which rapidly thickened. Water (5 ml) was added to aid mobility and the solid was collected by filtration, washed with water (5 ml) and dried in vacuo at ambient temperature to give 5-(4-chlorophenyl)-1-azaspiro[5.5]undec-4-ene 0.5 sulphate, 2.1 hydrate as a white solid. Yield 0.3 g, mp 205°-215° C.

後処理

  1. customto give
  2. filtrationthe solid was collected by filtration
  3. washwashed with water (5 ml)
  4. customdried in vacuo at ambient temperature

出典と根拠

ORDレコード
ord-a5d880275bbe46b8bbafc0240e40e2b8
出典データセット
uspto-grants-1997_03
特許番号
US05610161

反応ノート

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